GlpBio

GLP-1R Antagonist 1

目录号: GC36148纯度: >99.50%
GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的，胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性抑制，其IC50 值为 650 nM。
GLP-1R Antagonist 1
Cas No.: 488097-06-9
规格价格库存数量操作
1mg¥450.00现货
1
5mg¥990.00现货
1
10mg¥1,620.00现货
1
25mg¥3,150.00现货
1
50mg¥4,950.00现货
1
100mg¥7,650.00现货
1
10mM (in 1mL DMSO)¥1,089.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1]. IC50: 650 nM (GLP-1R)[1].

[1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
488097-06-9
SMILES
O=C1C2=C(NC(C3=CC=C(Cl)C=C3)=NC2(C(F)(F)F)C(F)(F)F)N(C)C(N1C)=O
分子式
C16H11ClF6N4O2
分子量
440.73 g/mol
溶解性
DMSO : 100 mg/mL (226.90 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol