Glabranine is a flavonoid isolated from Tephrosia species. Glabranine inhibits the dengue virus by interacting with the soluble extracellular domain of the DENV2 E protein. Glabranine can be used in research related to dengue virus inhibition, as well as for Glabranine antibacterial and antioxidant activities[1].
In vitro, Glabranine (6–50µM) was used to treat LLC-MK2 cells infected with dengue virus (serotype 2) for 24 hours. Glabranine exhibited no cytotoxicity to the cells and significantly inhibited dengue virus replication[2].
References:
[1] Ismail NA, Jusoh SA. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511.
[2] Sánchez I, Gómez-Garibay F, Taboada J, et al. Antiviral effect of flavonoids on the dengue virus. Phytother Res. 2000 Mar;14(2):89-92.
Glabranine是一种从Tephrosia s.p.中分离的黄酮类化合物。Glabranine通过与DENV2型E蛋白的可溶性胞外域相互作用来抑制登革热病毒。Glabranine可用于登革热病毒抑制和抗菌抗氧化相关研究[1]。
在体外，Glabranine（6–50µM）处理登革热病毒（血清型2）感染的LLC-MK2细胞24小时，对细胞无细胞毒性，并显著抑制登革热病毒复制[2]。