DLin-KC2-DMA is an ionizable cationic amino lipid (apparent pKa = 6.7) that has been used in combination with other lipids in the formation of lipid nanoparticles.1 Administration of Factor VII siRNA in DLin-KC2-DMA-containing LNPs reduces serum Factor VII protein levels in mice. LNPs containing DLin-KC2-DMA and androgen receptor siRNA decrease serum prostate-specific antigen (PSA) and tumor androgen receptor protein levels in an LNCaP mouse xenograft model.2
1.Semple, S.C., Akinc, A., Chen, J., et al.Rational design of cationic lipids for siRNA deliveryNat. Biotechnol.28(2)172-176(2010) 2.Lee, J.B., Zhang, K., Tam, Y.Y.C., et al.Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivoInt. J. Cancer131(5)E781-E790(2012)