Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities.1,2,3 It is active against P. falciparum in vitro (IC50 = 23 ?M).1 Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 ?M) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg.2 It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.3
1.Liu, K.C., Yang, S.L., Roberts, M.F., et al.Antimalarial activity of Artemisia annua flavonoids from whole plants and cell culturesPlant Cell Rep.11(12)637-640(1992) 2.Dai, W., Bi, J., Li, F., et al.Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn miceViruses11(7)625(2019) 3.Hong, G., He, X., Shen, Y., et al.Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone lossStem Cell Res. Ther.10(1)277(2019)