Arteannuin B is a precursor in the biosynthesis of the antimalarial artemisinin that has been found in A. annua and has diverse biological activities.1,2,3 It is active against a variety of bacteria and fungi, as well as plant pathogenic bacteria and fungi, in disk assays.1 Arteannuin B reduces viral RNA levels in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 10.28 ?M), acting at a post-entry step in the infection process.2 It is also cytotoxic to Ehrlich ascites tumor cells (IC50 = 47 ?M).3
1.Dhingra, V., Pakki, S.R., and Narasu, M.L.Antimicrobial activity of artemisinin and its precursorsCurr. Sci. India78(6)709-713(2000) 2.Cao, R., Hu, H., Li, Y., et al.Anti-SARS-CoV-2 potential of artemisinins in vitroACS Infect. Dis.6(9)2524-2531(2020) 3.Woerdenbag, H.J., Moskal, T.A., Pras, N., et al.Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cellsJ. Nat. Prod.56(6)849-856(1993)