tetranor-PGDM lactone-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM lactone by GC- or LC-mass spectrometry. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.2 tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.
1.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988)
2.Song, W.L., Wang, M., Ricciotti, E., et al.Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humansJ. Biol. Chem.283(2)1179-1188(2008)
