(+)-Baclofen is a GABAB receptor agonist.1,2 In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice.1 (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.2
1.Thomas, D.A., Navarrete, I.M., Graham, B.A., et al.Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of ratsBrain Res.718(1-2)129-137(1996) 2.Lorrai, I., Maccioni, P., Gessa, G.L., et al.R(+)-Baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring ratsFront. Psychiatry768(2016)