Ganoderic acid Y is HMG-CoA Reductase inhibitor and α-glucosidase inhibitor with IC50s of 8.6μM and 170μM, respectively [1,2]. Ganoderic acid Y can be used in cancer research.
In vitro，Ganoderic acid Y inhibited enterovirus 71 (EV71) replication through blocking EV71 uncoating[3]. Ganoderic acid Y inhibited the cell viabilities of K562 and PC-3 cell lines with IC50s of 17.5 and 179.8μM [2]. Ganoderic acid Y inhibited cell viability of H460 in concentration-dependent manner, with IC₅₀ of 22.4μM [4].
References:
[1]. Chen, Xian-Qiang, et al. "Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase." Phytochemistry 149 (2018): 103-115.
[2]. Wang, Kai, et al. "Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α-glucosidase." Journal of Natural Products 78.8 (2015): 1977-1989.
[3]. Zhang, Wenjing, et al. "Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection." Biochemical and biophysical research communications 449.3 (2014): 307-312.
[4]. Du, Guo-Hua, et al. "Anti-tumor target prediction and activity verification of Ganoderma lucidum triterpenoids." China Journal of Chinese Materia Medica 42.3 (2017): 517-522.
Ganoderic acid Y是HMG-CoA还原酶抑制剂和α-葡萄糖苷酶（α-glucosidase）抑制剂，其IC50值分别为8.6μM和170μM[1,2]。Ganoderic acid Y可用于癌症研究。
在体外研究中，Ganoderic acid Y通过阻止肠道病毒71型（EV71）的脱壳而抑制其复制[3]。Ganoderic acid Y可以抑制K562和PC-3细胞系的细胞活力，其IC50值分别为17.5和179.8μM[2]。Ganoderic acid Y以浓度依赖的方式抑制H460细胞的活力，其IC50为22.4μM[4]。