2,6-Diaminopimelic acid is a symmetrical α, α′-diamino dicarboxylic acid found in bacteria and higher plants [1]. 2,6-Diaminopimelic acid is a precursor for the biosynthesis of L-lysine and an important component of bacterial peptidoglycan [2]. 2,6-Diaminopimelic acid is a part of the bacteria that changes the bacteria (as a germ of bacteria). Presence or absence of 2,6-Diaminopimelic acid in the cell wall, classification of staphylococcal bacteria (containing 2,6-Diaminopimelic acid) and staphylococcal bacteria (containing staphylococcus acid) [3-4].
References:
[1]. Dzierzbicka K. Synthesis of 2, 6-diaminopimelic acid (DAP) and its analogues. Polish Journal of Chemistry. 2007; 81: 455-473.
[2]. Shaikh MS, Kale MA, Sharuk K. Discovery of Heterocyclic Analogs of Diaminopimelic Acid as Promising Antibacterial Agents Through Enzyme Targeted Inhibition of Lysine Biosynthesis. Current Enzyme Inhibition. 2018 Aug 1; 14(2): 120-130.
[3]. Masson HA, Denholm AM, Ling JR. In vivo metabolism of 2, 2'-diaminopimelic acid from gram-positive and gram-negative bacterial cells by ruminal microorganisms and ruminants and its use as a marker of bacterial biomass. Applied and environmental microbiology. 1991 Jun; 57(6): 1714-1720.
[4]. Bhamidi S, Shi L, Chatterjee D, et al. A bioanalytical method to determine the cell wall composition of Mycobacterium tuberculosis grown in vivo. Analytical biochemistry. 2012 Feb 1; 421(1): 240-249.
2,6-Diaminopimelic acid是一种对称的α,α′-二氨基二羧酸，存在于细菌和高等植物中 [1]。2,6-Diaminopimelic acid是L-lysine生物合成的前体，也是细菌肽聚糖的重要组成部分 [2]。2,6-Diaminopimelic acid是细菌的一部分，它能改变细菌（作为细菌的胚芽）。细胞壁中是否存在2,6-Diaminopimelic acid，可以区分葡萄球菌（含2,6-Diaminopimelic acid）和葡萄球菌（含葡萄球菌酸） [3-4]。