Finafloxacin is a fluoroquinolone antibiotic.1 It is active against S. pneumoniae and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) that is sensitive or resistant to fluoroquinolones (MIC90s = 2, 2, 0.125, and 4 mg/L, respectively). Finafloxacin (23.1 mg/kg) improves survival in F. tularensis- or Y. pestis-infected mice in models of tularemia or plague, respectively.2 Formulations containing finafloxacin have been used in the treatment of acute otitis externa.
1.Kocsis, B., Domokos, J., and Szabo, D.Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacinAnn. Clin. Microbiol. Antimicrob.15(1)34(2016) 2.Barnes, K.B., Richards, M.I., Laws, T.R., et al.Finafloxacin is an effective treatment for inhalational tularemia and plague in mouse models of infectionAntimicrob. Agents Chemother.65(6)e02294-02220(2021)