Palmitelaidic Acid (9-trans-Hexadecenoic acid) is a trans isomer of palmitoleic acid and dietary fatty acid that has been found in dairy fat products and various partially hydrogenated oils [1]. High levels of Palmitelaidic Acid in ovarian tissue are associated with poor prognosis and Palmitelaidic Acid can serve as a diagnostic biomarker for ovarian cancer [2]. Palmitelaidic Acid has been widely used as an additive to reduce the toxicity of resveratrol ester to the cell membrane of Corynebacterium glutamicum, and to increase the productivity and total yield of polyphenols[3].
In vitro, Palmitelaidic Acid treatment (300μM) for 72 hours significantly reduced the cell viability of undifferentiated bovine preadipocytes, and increased the contents of trans-11 vaccenic acid and total fatty acid content in bovine adipocytes[4].
References:
[1] Frigolet M E, Gutiérrez-Aguilar R. The role of the novel lipokine palmitoleic acid in health and disease[J]. Advances in Nutrition, 2017, 8(1): 173S-181S.
[2] Zhong X, Bilal M, Zhou Y, et al. Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues[J]. Frontiers in Oncology, 2025, 15: 1530487.
[3] Tharmasothirajan A, Melcr J, Linney J, et al. Membrane manipulation by free fatty acids improves microbial plant polyphenol synthesis[J]. Nature Communications, 2023, 14(1): 5619.
[4] Kadegowda A K G, Burns T A, Miller M C, et al. Cis-9, trans-11 conjugated linoleic acid is endogenously synthesized from palmitelaidic (C16: 1 trans-9) acid in bovine adipocytes[J]. Journal of Animal Science, 2013, 91(4): 1614-1623.
Palmitelaidic Acid (9-trans-Hexadecenoic acid)是palmitoleic acid的反式异构体，是一种在乳制品脂肪和各种部分氢化油中发现的膳食脂肪酸[1]。卵巢组织中高水平的Palmitelaidic Acid与不良预后相关，可作为卵巢癌的诊断生物标志物[2]。Palmitelaidic Acid已被广泛用作添加剂，以降低白藜芦醇酯对Corynebacterium glutamicum细胞膜的毒性，并提高多酚的产量和总产率[3]。
在体外，300µM的Palmitelaidic Acid处理72小时，显著降低了未分化的牛前脂肪细胞的细胞活力，并增加了牛脂肪细胞中反式-11-十八碳烯酸和总脂肪酸含量[4]。