Palmitelaidic Acid (9-trans-Hexadecenoic acid)
(Synonyms: 软脂酸; 9-trans-Hexadecenoic acid; trans-Palmitoleic acid) 目录号 : GC33765
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Palmitelaidic Acid (9-trans-Hexadecenoic acid)是palmitoleic acid的反式异构体，是一种在乳制品脂肪和各种部分氢化油中发现的膳食脂肪酸。
Cas No.:10030-73-6
Sample solution is provided at 25 µL, 10mM.
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Palmitelaidic Acid (9-trans-Hexadecenoic acid) is a trans isomer of palmitoleic acid and dietary fatty acid that has been found in dairy fat products and various partially hydrogenated oils [1]. High levels of Palmitelaidic Acid in ovarian tissue are associated with poor prognosis and Palmitelaidic Acid can serve as a diagnostic biomarker for ovarian cancer [2]. Palmitelaidic Acid has been widely used as an additive to reduce the toxicity of resveratrol ester to the cell membrane of Corynebacterium glutamicum, and to increase the productivity and total yield of polyphenols[3].
In vitro, Palmitelaidic Acid treatment (300μM) for 72 hours significantly reduced the cell viability of undifferentiated bovine preadipocytes, and increased the contents of trans-11 vaccenic acid and total fatty acid content in bovine adipocytes[4].
References:
[1] Frigolet M E, Gutiérrez-Aguilar R. The role of the novel lipokine palmitoleic acid in health and disease[J]. Advances in Nutrition, 2017, 8(1): 173S-181S.
[2] Zhong X, Bilal M, Zhou Y, et al. Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues[J]. Frontiers in Oncology, 2025, 15: 1530487.
[3] Tharmasothirajan A, Melcr J, Linney J, et al. Membrane manipulation by free fatty acids improves microbial plant polyphenol synthesis[J]. Nature Communications, 2023, 14(1): 5619.
[4] Kadegowda A K G, Burns T A, Miller M C, et al. Cis-9, trans-11 conjugated linoleic acid is endogenously synthesized from palmitelaidic (C16: 1 trans-9) acid in bovine adipocytes[J]. Journal of Animal Science, 2013, 91(4): 1614-1623.
Palmitelaidic Acid (9-trans-Hexadecenoic acid)是palmitoleic acid的反式异构体，是一种在乳制品脂肪和各种部分氢化油中发现的膳食脂肪酸[1]。卵巢组织中高水平的Palmitelaidic Acid与不良预后相关，可作为卵巢癌的诊断生物标志物[2]。Palmitelaidic Acid已被广泛用作添加剂，以降低白藜芦醇酯对Corynebacterium glutamicum细胞膜的毒性，并提高多酚的产量和总产率[3]。
在体外，300µM的Palmitelaidic Acid处理72小时，显著降低了未分化的牛前脂肪细胞的细胞活力，并增加了牛脂肪细胞中反式-11-十八碳烯酸和总脂肪酸含量[4]。
| Cell experiment [1]: | |
Cell lines | Bovine preadipocytes |
Preparation Method | Bovine preadipocytes were grown in DMEM medium with 10% (v/v) fetal bovine serum (FBS), 0.2mM glutamine, 100U/ml penicillin, and 100μg/ml streptomycin at 37°C in 5% CO2/atmosphere. Cells (5×104 cells/ml) were seeded in 24-well plates and allowed to adhere in a 5% CO2 incubator at 37°C overnight. Cells were treated with different concentrations of Palmitelaidic Acid (0, 50, 150, and 300μM) for 72h. The viability was evaluated. |
Reaction Conditions | 0, 50, 150, and 300μM; 72h |
Applications | Palmitelaidic Acid treatment significantly reduced the viability of bovine preadipocytes at concentrations higher than 150μM. |
References: | |
| Cas No. | 10030-73-6 | SDF | |
| 别名 | 软脂酸; 9-trans-Hexadecenoic acid; trans-Palmitoleic acid | ||
| Canonical SMILES | CCCCCC/C=C/CCCCCCCC(O)=O | ||
| 分子式 | C16H30O2 | 分子量 | 254.41 |
| 溶解度 | Ethanol : 100 mg/mL (393.07 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9307 mL | 19.6533 mL | 39.3066 mL |
| 5 mM | 786.1 μL | 3.9307 mL | 7.8613 mL |
| 10 mM | 393.1 μL | 1.9653 mL | 3.9307 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet