F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].
F13714 targets 5-HT1A autoreceptors[1].
In UCMS mice, a single administration of F13714 (4-16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naÏve rats[1].
[1]. Monika G?uch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10.