ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good psicochemical properties and neuroprotective properties.
ENT-C225 (Compound 10) (1 µM; 24 h) significantly improves NIH-3T3 TrkB cytotoxicity and reduces cell mortality[1].ENT-C225 (1 µM; 20 min) promotes TrkB receptor phosphorylation in NIH-3T3 TrkB cells and primary astrocytes[1].ENT-C225 (500 pM-1 µM; 48 h) has significant neuroprotective effect and enhances in a dose-dependent manner. ENT-C225 promoting the accumulation of TAR DNA-binding protein 43 (TDP43) in the neural network and cytoplasm of spinal motor neurons[1].
References:
[1]. Antonijevic M, et al. Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor. Eur J Med Chem. 2023 Feb 15;248:115111.