GlpBio

EBNA1-IN-SC7

目录号: GC73003纯度: >99.00%
EBNA1-IN-SC7（化合物SC7）是一种选择性EBNA1 （Epstein-Barr nuclear antigen 1）抑制剂，干扰EBNA1- dna结合活性，IC50值为23 μM。
EBNA1-IN-SC7
Cas No.: 324022-08-4
规格价格库存数量操作
5 mg¥1,215.00现货
1
10 mg¥1,980.00现货
1
25 mg¥3,960.00现货
1
10mM (in 1mL DMSO)¥1,336.00现货
1
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC50 value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research.

EBNA1-IN-SC7 (compound SC7) (5 µM) can completely block transcriptional activation of EBNA1 and show a 60% inhibition of Zta (EBV-encoded b-zip DNA binding protein) trans-activation in HEK293T cells[2].EBNA1-IN-SC7 (compound SC7) (10 µM, 6 days) has no significant effect on EBV genome copy number of Raji Burkitt lymphoma cells[2].

References:
[1]. Lijun Jiang, et al. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics. 2018 Oct 22;8(19):5307-5319.
[2]. Ning Li, et al. Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. PLoS One. 2010 Apr 12;5(4):e10126.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
324022-08-4
分子式
C20H16BrNO5S
分子量
462.31 g/mol
溶解性
DMSO : 100 mg/mL (216.31 mM; ultrasonic and warming and heat to 60°C)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol