EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
[1] Elena Mariotto, et al. Cancers (Basel). 2018 Oct 22;10(10):391. [2] Elena Mariotto, et al. Biochem Pharmacol. 2018 Sep;155:213-223.
















