3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside is a stilbene glucoside that has been found in V. vinifera and has diverse biological activities.1,2,3,4,5 It reduces the growth of SKOV3 ovarian cancer cell 3D aggregates in a concentration-dependent manner.2 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (10 and 20 ?g/ml) inhibits IL-17 production in activated peripheral blood mononuclear cells (PBMCs).3 It inhibits the loss of glutathione peroxidase 4 (GPX4) activity induced by the ferroptosis inducer hemin in Neuro2a neuroblastoma cells.4 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (50 mg/kg) reduces escape latency in a rat model of vascular dementia induced by four-vessel occlusion (4-VO).5
1.Teguo, P.W., Fauconneau, B., Deffieux, G., et al.Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell culturesJ. Nat. Prod.61(5)655-677(1998) 2.Hogg, S.J., Chitcholtan, K., Hassan, W., et al.Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell linesObstet. Gynecol. Int.279591(2015) 3.Lanzilli, G., Cottarelli, A., Nicotera, G., et al.Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulationInflammation35(1)240-248(2012) 4.Huang, L., He, S., Cai, Q., et al.Polydatin alleviates traumatic brain injury: Role of inhibiting ferroptosisBiochem. Biophys. Res. Commun.556149-155(2021) 5.Li, R.-P., Wang, Z.-Z., Sun, M.-X., et al.Polydatin protects learning and memory impairments in a rat model of vascular dementiaPhytomedicine19(8-9)677-681(2012)