GlpBio

PLGA(75:25)(poly(lactic-co-glycolic acid))

目录号: GC30049纯度: 不显示|不显示|不显示|不显示|不显示|不显示同义词: 聚乳酸-羟基乙酸共聚物; poly(lactic-co-glycolic acid
COASDSData Sheet

PLGA. 聚乳酸-羟基乙酸共聚物 (poly (lactic-co-glycolic acid),PLGA)由两种单体——乳酸和羟基乙酸随机聚合而成,是一种可降解的功能高分子有机化合物,具有良好的生物相容性、无毒、良好的成囊和成膜的性能,被广泛应用于制药、医用工程材料和现代化工业领域PLGA@Icaritin NPs与游离Icaritin相比,可以显著抑制细胞生长,诱导乳酸脱氢酶(LDH)渗漏,在G2期阻滞更多的GC细胞,抑制GC细胞的侵袭和转移。

PLGA(75:25)(poly(lactic-co-glycolic acid))
Cas No.: 34346-01-5
规格价格库存数量操作
500mg¥585.00现货
1
1g¥990.00现货
1
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产品描述 Description

PLGA(poly (lactic-co-glycolic acid)) is made by random polymerization of two monomers: lactic acid and glycolic acid. It is a degradable functional polymer organic compound with good biocompatibility, non-toxic, and good cystforming and film forming properties. It is widely used in pharmaceutical, medical engineering materials and modern industrial fields[1,2].

PLGA@Icaritin nanoparticles (NPs) dramatically suppressed cell growth, induced Lactic dehydrogenase (LDH) leakage, arrested more GC cells at G2 phase, and inhibited the invasion and metastasis of GC cells, compared to free icaritin. In addition, PLGA@Icaritin could help generate dozens of reactive oxygen species (ROS) within GC cells, following by significant mitochondrial membrane potentials (MMPs) loss and excessive production of oxidative-mitochondrial DNA (Ox-mitoDNA)[3].

References:
[1]. Gentile P, Chiono V, et,al. An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. Int J Mol Sci. 2014 Feb 28;15(3):3640-59. doi: 10.3390/ijms15033640. PMID: 24590126; PMCID: PMC3975359.
[2]. Sadat Tabatabaei Mirakabad F, Nejati-Koshki K, et,al.PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 2014;15(2):517-35. doi: 10.7314/apjcp.2014.15.2.517. PMID: 24568455.
[3]. Xiao Y, Yao W, et,al.Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer. Drug Deliv. 2022 Dec;29(1):1712-1725. doi: 10.1080/10717544.2022.2079769. PMID: 35635307; PMCID: PMC9176696.

PLGA. 聚乳酸-羟基乙酸共聚物 (poly (lactic-co-glycolic acid),PLGA)由两种单体——乳酸和羟基乙酸随机聚合而成,是一种可降解的功能高分子有机化合物,具有良好的生物相容性、无毒、良好的成囊和成膜的性能,被广泛应用于制药、医用工程材料和现代化工业领域[1,2]

PLGA@Icaritin NPs与游离Icaritin相比,可以显著抑制细胞生长,诱导乳酸脱氢酶(LDH)渗漏,在G2期阻滞更多的GC细胞,抑制GC细胞的侵袭和转移。此外,PLGA@Icaritin可以帮助在GC细胞内产生数十种活性氧(ROS),造成显著的线粒体膜电位(MMPs)损失和氧化线粒体DNA (Ox-mitoDNA)的过度产生[3]。

实验参考方法 Experimental Reference Method

Protocol 1 (Synthesis of PLGA@ Icaritin )[1]：
1.PLGA-PEG copolymers (PEG2000) were prepared by melt polymerization under vacuum using stannous octoate [stannous 2-ethylhexanoate] as a catalyst.  PLGA and PEG2000 (0.77 g) (45%/w) were heated to 140℃ in a bottleneck flask under a nitrogen atmosphere for complete melting. (The molar ratio of DL-lactide to glycolide was 3:1 in PLGA)
2.Stannous octoate [0.05% (w/w)] was added, and the temperature of the reaction mixture was increased to 180℃. This temperature was maintained for 4 h. Polymerization was performed under vacuum.
3.The copolymer was recovered by dissolution in methylene chloride, followed by precipitation in ice-cold diethyl ether. After 24 h, PLGA-PEG was purified by washing with ethanol and drying under vacuum.
4.Icaritin (0.5 mg) was dissolved in 500 μL dimethyl sulfoxide and mixed with 5 mg of PLGA-PEG in the drug solution.
5.The drug-polymer mixture was added dropwise to 10 mL of deionized water while stirring and stirred for 24 h at room temperature in a beaker.
6.PLGA@Icaritin was obtained, dialyzed to remove the organic solvent, and freeze-dried.
  1. This protocol only provides a guideline, and should be modified according to your specific needs.

References:

[1]. Xiao Y, Yao W, et,al. Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer. Drug Deliv. 2022 Dec;29(1):1712-1725. doi: 10.1080/10717544.2022.2079769. PMID: 35635307; PMCID: PMC9176696. 

产品文档 Product Documents

COASDSData Sheet

化学性质Chemical Properties

CAS 号
34346-01-5
同义词
聚乳酸-羟基乙酸共聚物; poly(lactic-co-glycolic acid
SMILES
O=C(O)C(C)OC(CO[H])=O.[x].[y]
分子式
(C5H8O5)n
分子量
10000-20000 g/mol
溶解性
DMSO : 100 mg/mL ;chloroform : 16.67 mg/mL ;Water : < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol