Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
Danthron (Dantron)
目录号: GC30056纯度: >98.50%同义词: 1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
Cas No.: 117-10-2
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 100mg | ¥446.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥491.00 | 现货 | 1 |
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产品描述 Description
实验参考方法 Experimental Reference Method
Cell experiment: | HepG2 cells are transfected with pGL3-ABCA1 promoter-luc or pGL3-ABCG1 promoter-luc and pRL-SV40 plasmids. At 6 h post-transfection, the cells are incubated with Danthron (0-20 μM), TO90 (2 μM) or DMSO for 24 h. Luciferase activity is measured using the Dual Luciferase Reporter Assay kit[1]. |
Animal experiment: | Mice[2]C57/BL6 male mice are fed with a high fat diet for 3 months and treated with Danthron (5 mg/kg) or vehicle orally for 8 weeks. The animals are then fasted for 6 h and then given intraperitoneal injection of insulin at 1.5 units/kg. Blood samples are analyzed at 15, 30, 45, 60, 90, and 120 min using Accu-Chek active blood sugar test meter. |
References: [1]. Zhou R, et al. Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro. Acta Pharmacol Sin. 2013 Aug;34(8):1061-9. |
产品文档 Product Documents
Purity:>98.50%
化学性质Chemical Properties
CAS 号
117-10-2
同义词
1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
SMILES
O=C1C2=C(C=CC=C2O)C(C3=CC=CC(O)=C13)=O
分子式
C14H8O4
分子量
240.21 g/mol
溶解性
DMSO : ≥ 42 mg/mL (174.85 mM)
保存条件
Store at 4°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol