Fosfomycin is a broad-spectrum bactericidal antibiotic.1,2 It is active against Salmonella and P. aeruginosa at 1.56 and 6.25 ?g/ml, respectively, as well as methicillin-sensitive S. aureus (MSSA), cephalosporin- and penicillin-resistant S. pneumoniae, methicillin-resistant S. aureus (MRSA), and vancomycin-resistant Enterococcus. Formulations containing fosfomycin have been used in the treatment of urinary tract infections.
1.Goto, S.Fosfomycin, antimicrobial activity in vitro and in vivoChemotherapy23(Suppl. 1)63-74(1977) 2.Michalopoulos, A.S., Livaditis, I.G., and Gougoutas, V.The revival of fosfomycinInt. J. Infect. Dis.15(11)e732-e739(2011)