C24 (2'(R)-hydroxy) Phytoceramide is a naturally occurring sphingolipid that has been found in adlay seed hull.1 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and inducible nitric oxide synthase (iNOS) levels. It increases production of chemokine (C-X-C motif) ligand 8 (CXCL8), CXCL1, chemokine (C-C motif) ligand 2 (CCL2), and CCL20 in human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.2 C24 (2'(R)-hydroxy) Phytoceramide is a hydroxylated form of C24 phytoceramide . [Matreya, LLC. Catalog No. 2094]
|1. Huang, D.-W., Chung, C.-P., Kuo, Y.-H., et al. Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J. Agric. Food Chem. 57(22), 10651-10657 (2009).|2. Sekiya, M., Ueda, K., Okazaki, K., et al. A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells. Int. Immunopharmacol. 11(10), 1497-1503 (2011).