C17 Ceramide (d18:1/17:0) is a synthetic ceramide containing a non-natural C17:0 fatty acid acylated to sphingosine[1]. Ceramide regulates many different biological activities, such as apoptosis, cell differentiation, smooth muscle cell proliferation, and inhibition of the mitochondrial respiratory chain[2, 3]. C17 Ceramide (d18:1/17:0) can be used as an internal standard or reference for mass spectrometry (LC-MS/MS) or chromatography (HPLC) analysis of natural ceramides in biological samples[4, 5]. C17 Ceramide (d18:1/17:0) can be used as a potential biomarker to distinguish metabolically healthy obesity (MHO) from metabolically unhealthy obesity (MUO)[6].
References:
[1] Huang Q, Hao S, Yao X, et al. Quantitative LCMS for ceramides/dihydroceramides: Pregnancy baseline biomarkers and potential metabolic messengers[J]. bioRxiv, 2020: 2020.02. 24.963462.
[2] Birbes H, El Bawab S, Obeid L M, et al. Mitochondria and ceramide: intertwined roles in regulation of apoptosis[J]. Advances in enzyme regulation, 2002, 42: 113-129.
[3] Kogot-Levin A, Saada A. Ceramide and the mitochondrial respiratory chain[J]. Biochimie, 2014, 100: 88-94.
[4] Kasumov T, Huang H, Chung Y M, et al. Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry[J]. Analytical Biochemistry, 2010, 401(1): 154-161.
[5] Qiu L P, Sun W J. Simultaneous quantitative analysis of different ceramide species in cells by high-performance liquid chromatography-tandem mass spectrometry[J]. Zhejiang da xue xue bao. Yi xue ban= Journal of Zhejiang University. Medical Sciences, 2015, 44(4): 429-434.
[6] Yu B, Hu M, Jiang W, et al. Ceramide d18: 1/24: 1 as a potential biomarker to differentiate obesity subtypes with unfavorable health outcomes[J]. Lipids in Health and Disease, 2023, 22(1): 166.
C17 Ceramide (d18:1/17:0)是一种合成神经酰胺，含有酰化为鞘氨醇的非天然 C17:0脂肪酸[1]。神经酰胺调节许多不同的生物活动，例如细胞凋亡、细胞分化、平滑肌细胞增殖和线粒体呼吸链的抑制等[2, 3]。C17 Ceramide (d18:1/17:0)能够作为内标（internal standard）或参照物，用于质谱（LC-MS/MS）或色谱（HPLC）分析生物样本中的天然神经酰胺[4, 5]。C17 Ceramide (d18:1/17:0)能够作为一种潜在的生物标志物来区分代谢健康肥胖（MHO）和代谢不健康肥胖（MUO）[6]。