Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).1 It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m3, respectively.2 Pyridaben is toxic to rats when administered orally (LD50s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD50s = 0.62 and 0.66 mg/L for female and male rats, respectively).3 Formulations containing pyridaben have been used in the control of mites in agriculture.
1.Navarro, A., BÁndez, M.J., GÓmez, C., et al.Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activityJ. Bioenerg. Biomembr.42(5)405-412(2010) 2.Takahashi, M., Shono, T., and Umehara, T.Efficacy of pyridaben against three kinds of mites, Cheyletus malaccensis, Dermatophagoides farinae and Tyrophagus putrescentiaeJpn. J. Sanit. Zool.41(3)257-260(1990) 3.Igarashi, H., and Sakamoto, S.Summary of toxicity studies with pyridabenJ. Pest. Scien.19(4)S243-S251(1994)