Cyclophosphamide-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of cyclophosphamide by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.1,2 In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug and is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.3,4
1.Yildirim-Toruner, C., and Diamond, B.Current and novel therapeutics in the treatment of systemic lupus erythematosusJ. Allergy Clin. Immunol.127(2)303-314(2011) 2.Appel, G.B.New and future therapies for lupus nephritisCleve. Clin. J. Med.79(2)134-140(2012) 3.Ahmed, A.R., and Hombal, S.M.Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical usesJ. Am. Acad. Dermatol.11(6)1115-1126(1984) 4.Bischoff, P.L., Holl, V., Coelho, D., et al.Apoptosis at the interface of immunosuppressive and anticancer activities: The examples of two classes of chemical inducers, oxysterols and alkylating agentsCurr. Med. Chem.7(7)693-713(2000)