CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).1 It dose-dependently reduces levels of the SCD desaturation products palmitoleic acid and vaccenic acid in the plasma and liver of rats fed a high-sucrose diet. CVT-12012 (20 mg/kg) also reduces hepatic triglyceride levels in sucrose-fed rats.
1.Koltun, D.O., Zilbershtein, T.M., Migulin, V.A., et al.Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitorsBioorg. Med. Chem. Lett.19(15)4070-4074(2009)