Cosyntropin (acetate) is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Cosyntropin (acetate) is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis[1].
Under the stimulation of Cosyntropin (acetate) (10nM; 48h), PregS and Preg in adrenal cells showed an acute response (increased 21-fold and 12-fold respectively over the baseline within 3h) and reached a peak after 24h. In contrast, DHEAS and DHEA did not respond much to Cosyntropin (acetate) stimulation (increased 1.8-fold and 2.8-fold respectively over the baseline after 3h). After 48h of Cosyntropin (acetate) stimulation, PregS levels decreased slightly, Preg content decreased sharply, and DHEAS levels continued to increase slightly [2].
Cosyntropin (acetate) (0.2μg/kg/day; SC; 24d) stimulates vascular endothelial growth factor production in vivo and induces vascular endothelial growth factor secretion from osteoblasts via the pro-adrenocorticotropic hormone receptor, MC2R, which supports osteoblast maturation and survival in vitro[3]. Reduced microglia/macrophage accumulation and neutrophil infiltration in conjunction with moderate improvements in spatial learning in Cosyntropin (acetate) treated TBI mice[4].
References:
[1]Iuliano F, Iuliano E, Rossi M. Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation[J]. Blood, 2018, 132: 2449.
[2]. Rege J, Nanba A T, Auchus R J, et al. Adrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro[J]. The Journal of Clinical Endocrinology & Metabolism, 2018, 103(1): 320-327.
[3].Zaidi M, Sun L, Robinson L J, et al. ACTH protects against glucocorticoid-induced osteonecrosis of bone[J]. Proceedings of the National Academy of Sciences, 2010, 107(19): 8782-8787.
[4]. Siebold L, Krueger A C, Abdala J A, et al. Cosyntropin attenuates neuroinflammation in a mouse model of traumatic brain injury[J]. Frontiers in Molecular Neuroscience, 2020, 13: 109.
Cosyntropin (acetate)是一种合成肽，可刺激肾上腺释放皮质类固醇，如皮质醇。Cosyntropin (acetate)目前用于研究溃疡性结肠炎和克罗恩病、幼年/成人类风湿性关节炎和骨关节病[1]。
在Cosyntropin (acetate)（10nM；48h）刺激条件下，肾上腺细胞中PregS和Preg表现出急性反应（3h内分别比基线增加21倍和12倍），并在 24h后达到峰值。相比之下，DHEAS和DHEA对Cosyntropin (acetate)的刺激反应不大（3h后分别比基线增加1.8倍和2.8倍）。Cosyntropin (acetate)刺激48h后，PregS水平略有下降，Preg含量急剧下降，而DHEAS水平继续小幅上升[2]。
在糖皮质激素诱导的骨坏死模型中，Cosyntropin (acetate)（0.2μg/kg/day）可刺激体内血管内皮生长因子的产生，并通过促肾上腺皮质激素受体MC2R诱导成骨细胞分泌血管内皮生长因子，从而支持体外成骨细胞的成熟和存活[3]。经Cosyntropin (acetate)治疗的创伤性脑损伤小鼠的小胶质细胞/巨噬细胞聚集和中性粒细胞浸润减少，空间学习能力得到适度改善[4]。