CID797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 ?M).1 It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 ?M, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 ?M. CID797718 is a byproduct in the synthesis of CID755673 .2
1.Sharlow, E.R., Giridhar, K.V., LaValle, C.R., et al.Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinoloneJ. Biol. Chem.283(48)33516-33526(2008) 2.Lavalle, C.R., Bravo-Altamirano, K., Gorodhar, K.V., et al.Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motilityBMC Chem Biol.10(5)(2010)