CARM1 degrader-1 drochloride is the drochloride salt form of CARM1 degrader-1 . CARM1 degrader-1 drochloride is a PROTAC degrader for co-activator associated argininemetltransferase 1 (CARM1), which degrades CARM1 in a VHL- and proteasome-dependent manner with a DC50 of 8.1 nM. CARM1 degrader-1 drochloride inhibits metlation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, and thus inhibits breast cancer cell migration.
References:
[1]. Xie H, et al., Development of Potent and Selective Coactivator-Associated Arginine Metltransferase 1 (CARM1) Degraders. J Med Chem. 2023 Sep 28;66(18):13028-13042.