GlpBio

Capmatinib dihydrochloride hydrate

目录号: GC68828纯度: >99.50%同义词: 卡马替尼盐酸盐水合物; INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate
Capmatinib (INC280; INCB28060) dihydrochloride hydrate 是一种有效的、口服活性的、选择性的、ATP 竞争性的 c-Met 激酶抑制剂 (IC50=0.13 nM)。Capmatinib dihydrochloride hydrate 可抑制 c-MET 的磷酸化，以及 c-MET 通路下游效应蛋白如 ERK1/2、AKT、FAK、GAB1 和 STAT3/5。Capmatinib dihydrochloride hydrate 有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，并有效诱导细胞凋亡。在肿瘤小鼠模型中表现出抗肿瘤活性。Capmatinib dihydrochloride hydrate 主要由 CYP3A4 和醛氧化酶代谢。
Capmatinib dihydrochloride hydrate
Cas No.: 1865733-40-9
规格价格库存数量操作
10mg¥693.00现货
1
50mg¥2,025.00现货
1
100mg¥3,240.00现货
1
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产品描述 Description

Capmatinib (INC280; INCB28060) didrochloride drate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib didrochloride drate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2,

[1]. Liu X, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.
[2]. Baltschukat S, et al. Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation. Clin Cancer Res. 2019 May 15;25(10):3164-3175.
[3]. Dhillon S. Capmatinib: First Approval. Drugs. 2020 Jul;80(11):1125-1131.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1865733-40-9
同义词
卡马替尼盐酸盐水合物; INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate
分子式
C23H21Cl2FN6O2
分子量
503.36 g/mol
溶解性
DMSO : 20.83 mg/mL (41.38 mM; ultrasonic and warming and heat to 60°C)
保存条件
4°C, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol