Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency.
Calcium dobesilate effectively inhibits cell apoptosis in venous wall of primary varicose veins by regulating the expression of Bcl-2 and p53[1].
[1] Iriz E, et al. Vasa. 2008, 37(3):233-40. [2] Cai T, et al. DNA Cell Biol. 2017, 36(4):249-255.
















