BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity.
BW-A 78U
目录号: GC31915纯度: >99.50%
BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity.
Cas No.: 101155-02-6
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥336.00 | 现货 | 1 | |
| 5mg | ¥802.00 | 现货 | 1 | |
| 10mg | ¥1,193.00 | 现货 | 1 | |
| 25mg | ¥2,003.00 | 现货 | 1 | |
| 50mg | ¥2,948.00 | 现货 | 1 | |
| 100mg | ¥4,174.00 | 现货 | 1 |
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Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
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产品描述 Description
实验参考方法 Experimental Reference Method
Cell experiment: | Mononuclear cells are incubated for 30 min with BW-A 78U at the concentration of 10 nM to 10 μM. The cells are then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants are collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants are determined by specific ELISA using a commercial kit. Sensitivity of the assay is 1 pg/mL. The absorbance at 450 nm is assessed with an ELISA reader[1]. |
References: [1]. Boichot E, et al. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derivedfrom 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53. |
产品文档 Product Documents
Purity:>99.50%
化学性质Chemical Properties
CAS 号
101155-02-6
SMILES
CNC1=C2N=CN(CC3=CC=CC=C3F)C2=NC=N1
分子式
C13H12FN5
分子量
257.27 g/mol
溶解性
DMSO : 150 mg/mL (583.05 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol