Bometolol Hydrochloride

目录号: GC32665纯度: >98%同义词: 波美洛尔盐酸盐

BometololHydrochloride是一种beta-adrenergic阻滞剂，可用于高血压等心血管疾病的研究。

Cas No.: 65023-16-7

规格	价格	库存	数量
1mg	¥20,528.00	现货	1
5mg	¥51,408.00	现货	1
10mg	¥87,376.00	现货	1

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Cell
187(9):2288-2304 (2024)
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183(7):1867-1883 (2020)
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388(6745) (2025)
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产品描述 Description

Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.

Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats[1].

[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12.

实验参考方法 Experimental Reference Method

Animal experiment:

Rats[1]In the acute experments, normal female Donryu strain (DON, 14-15 weeks, 250-270 g), and SHR (17-18 weeks, 180-200 g), DOC (7-9 weeks, 180-210 g), and CLIP (7-9 weeks, 180-210 g) hypertensive rats are used. Bometolol hydrochloride is dissolved in H2O and 0.01% Tween 80 solution at a volume of 5 mL/kg body weight for the acute and subchronic studies, respectively. The doses are in terms of the free base. The solution is administratered orally by a gastric tube. In the acute experiment, H2O (5 mL/kg) is giver to the control groups. In the subchronic experment, the drug is administered once a day for 5 weeks, 5 days per week, and Tween 80 solution (5 mL/kg) is given to the control groups[1].

References:

[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12.

产品文档 Product Documents

Purity:>98%

COA SDS Data Sheet

化学性质Chemical Properties

CAS 号

65023-16-7

同义词

波美洛尔盐酸盐

SMILES

O=C1NC2=C(C(OCC(O)CNCCC3=CC=C(OC)C(OC)=C3)=CC=C2OCC(C)=O)CC1.[H]Cl

分子式

C₂₅H₃₃ClN₂O₇

分子量

508.99 g/mol

溶解性

Soluble in DMSO

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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