IC50: 5.9 nM (BLK)[1], 202.0 nM (BTK)[1]
BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits Btk (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].
[1]. Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). Eur J Med Chem. 2022 Feb 5;229:114051.