BIO8898 is a potent CD40-CD154 inhibitor. BIO8898 inhibits soluble CD40L binding to CD40-Ig with an IC50 value of 25 µM. BIO8898 inhibits CD40L-induced Apoptosis[1].
BIO8898 (0-100 µM; 3 days) inhibits CD40L-induced apoptosis in a dose-dependent manner[1].
Apoptosis Analysis[1]
| Cell Line: | CD40-TNFR-BHK cells |
| Concentration: | 0-100 µM |
| Incubation Time: | 3 days |
| Result: | Inhibited the ability of 3 ng/ml mycCD40L plus 50 μg/ml cyclohexamide to induce apoptosis. |
[1]. Silvian LF, et al. Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol. 2011 Jun 17;6(6):636-47.