GlpBio

BI-2545

目录号: GC60074纯度: >99.50%
An inhibitor of autotaxin
BI-2545
Cas No.: 2162961-71-7
规格价格库存数量操作
5mg¥855.00现货
1
10mg¥1,260.00现货
1
25mg¥2,250.00现货
1
50mg¥3,375.00现货
1
100mg¥5,040.00现货
1
10mM (in 1mL DMSO)¥990.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

BI-2545 is an inhibitor of autotaxin (IC50s = 2.2 and 3.4 for the human and rat enzyme, respectively).1 It is selective for autotaxin over a panel of 48 enzymes, transporters, ion channels, and receptors at 10 ?M. BI-2545 (10 mg/kg) reduces plasma lysophosphatidic acid (LPA) levels in rats.

1.Kuttruff, C.A., Ferrara, M., Bretschneider, T., et al.Discovery of BI-2545: A novel autotaxin inhibitor that significantly reduces LPA levels in vivoACS Med. Chem. Lett.8(12)1252-1257(2017)

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2162961-71-7
SMILES
O=C(N1C[C@]2([H])[C@H](CNC(C3=CC=C(NN=N4)C4=C3)=O)[C@]2([H])C1)OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5
分子式
C23H19F6N5O3
分子量
527.42 g/mol
溶解性
DMSO: 250 mg/mL (474.01 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol