Penicillin G Sodium is an antibiotic containing a β-lactam ring against sensitive organisms [1]. Penicillin G Sodium binds to penicillin-binding proteins (PBPs) of bacteria which are involved in cell wall synthesis and thus inhibit bacterial cell wall synthesis [2]. Penicillin G Sodium has been widely used to kill Staphylococcus aureus, and to develop a combined therapy with lactoferrin to induce the lysis of various bacteria and changes in the cell wall[3].
In vitro, Penicillin G Sodium treatment (150U/ml) for 48 hours led to the formation of abnormal Chlamydia trachomatis (CT) inclusions within HeLa cells infected with CT and without causing cytotoxicity, and altered the mRNA expression profile of CT[4].
In vivo, Penicillin G Sodium treatment (160mg/kg; s.c.) combined with gentamicin (10mg/kg; s.c.) twice daily for 5 days can significantly increase the survival rate of mice with penicillin-resistant pneumococcal pneumonia [5].
References:
[1] Chu L, Zhuang S, Wang J. Degradation kinetics and mechanism of penicillin G in aqueous matrices by ionizing radiation[J]. Radiation Physics and Chemistry, 2018, 145: 34-38.
[2] Li D, Yang M, Hu J, et al. Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river[J]. Water Research, 2008, 42(1-2): 307-317.
[3] Diarra M S, Lacasse P, Deschênes E, et al. Ultrastructural and cytochemical study of cell wall modification by lactoferrin, lactoferricin and penicillin G against Staphylococcus aureus[J]. Journal of electron microscopy, 2003, 52(2): 207-215.
[4] Wang M, Qiu X, Xu Y, et al. Impacts of penicillin G on Chlamydia trachomatis serovar D and host HeLa cells in genital infections[J]. Archives of Microbiology, 2025, 207(7): 164.
[5] Tateda K, Matsumoto T, Miyazaki S, et al. Efficacy of β-lactam antibiotics combined with gentamicin against penicillin-resistant pneumococcal pneumonia in CBA/J mice[J]. Journal of Antimicrobial Chemotherapy, 1999, 43(3): 367-371.
Penicillin G Sodium是一种含有β-内酰胺环的抗生素，对敏感微生物有效[1]。Penicillin G Sodium可与细菌中参与细胞壁合成的青霉素结合蛋白结合，从而抑制细菌细胞壁的合成[2]。Penicillin G Sodium已被广泛用于杀灭金黄色葡萄球菌，并与乳铁蛋白一起开发联合疗法，以诱导多种细菌的裂解和细胞壁的改变[3]。
在体外，150U/ml的Penicillin G Sodium处理感染沙眼衣原体(CT)的HeLa细胞48小时，导致异常CT包涵体的形成，且不产生细胞毒性，同时改变了CT的mRNA表达谱 [4]。
在体内，Penicillin G Sodium（160mg/kg；s.c.）联合庆大霉素（10 mg/kg；s.c.），每日两次，连续5天，可显著提高青霉素耐药肺炎球菌肺炎小鼠的存活率[5]。