Benzyl alcohol (Benzenemethanol) is an aromatic alcohol widely used in medicine, cosmetics, food and industry[1, 2]. Benzyl alcohol can be used as a local anesthetic for short-term superficial skin surgery[3]. Benzyl alcohol is naturally produced by many plants and is commonly found in fruits and teas, as well as in various essential oils[4].
In vivo, Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with acetaminophen (APAP)-induced liver injury, which significantly reduced plasma alanine aminotransferase (ALT) activity, reduced the area of liver lobule necrosis, and alleviated APAP-induced liver injury[5]. Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with APAP-induced liver injury, which inhibited the release of cytokines, chemokines, and high-mobility group protein 1, and suppressed inflammasome signaling[6].
References:
[1] Scognamiglio J, Jones L, Vitale D, et al. Fragrance material review on benzyl alcohol[J]. Food and Chemical Toxicology, 2012, 50: S140-S160.
[2] Chan-Thaw C E, Savara A, Villa A. Selective benzyl alcohol oxidation over Pd catalysts[J]. Catalysts, 2018, 8(10): 431.
[3] Wilson L, Martin S. Benzyl alcohol as an alternative local anesthetic[J]. Annals of emergency medicine, 1999, 33(5): 495-499.
[4] Sell C. Chemistry of essential oils[M]//Handbook of essential oils. CRC Press, 2020: 161-189.
[5] Du K, McGill M R, Xie Y, et al. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses[J]. Food and Chemical Toxicology, 2015, 86: 253-261.
[6] Cai C, Huang H, Whelan S, et al. Benzyl alcohol attenuates acetaminophen‐induced acute liver injury in a Toll‐like receptor‐4‐dependent pattern in mice[J]. Hepatology, 2014, 60(3): 990-1002.
Benzyl alcohol (Benzenemethanol)是一种芳香醇，广泛应用于医药、化妆品、食品和工业领域[1, 2]。Benzyl alcohol能够被用作短期浅表皮肤手术的局部麻醉剂[3]。Benzyl alcohol是由许多植物自然产生的，通常存在于水果和茶中，也存在于各种精油中[4]。
在体内，Benzyl alcohol（270mg/kg）通过腹腔注射治疗对乙酰氨基酚（APAP）诱导的肝损伤小鼠，显著降低了血浆丙氨酸氨基转移酶（ALT）的活性，减少了肝小叶的坏死面积，减轻了APAP诱导的肝损伤[5]。Benzyl alcohol（270mg/kg）通过腹腔注射治疗治疗对APAP诱导的肝损伤小鼠，抑制了细胞因子和趋化因子以及高迁移率族蛋白1的释放，抑制了炎症小体信号转导[6]。