Benzyl alcohol (Benzenemethanol)是一种芳香醇，广泛应用于医药、化妆品、食品和工业领域。
Cas No.:100-51-6
Sample solution is provided at 25 µL, 10mM.
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Benzyl alcohol (Benzenemethanol) is an aromatic alcohol widely used in medicine, cosmetics, food and industry[1, 2]. Benzyl alcohol can be used as a local anesthetic for short-term superficial skin surgery[3]. Benzyl alcohol is naturally produced by many plants and is commonly found in fruits and teas, as well as in various essential oils[4].
In vivo, Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with acetaminophen (APAP)-induced liver injury, which significantly reduced plasma alanine aminotransferase (ALT) activity, reduced the area of liver lobule necrosis, and alleviated APAP-induced liver injury[5]. Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with APAP-induced liver injury, which inhibited the release of cytokines, chemokines, and high-mobility group protein 1, and suppressed inflammasome signaling[6].
References:
[1] Scognamiglio J, Jones L, Vitale D, et al. Fragrance material review on benzyl alcohol[J]. Food and Chemical Toxicology, 2012, 50: S140-S160.
[2] Chan-Thaw C E, Savara A, Villa A. Selective benzyl alcohol oxidation over Pd catalysts[J]. Catalysts, 2018, 8(10): 431.
[3] Wilson L, Martin S. Benzyl alcohol as an alternative local anesthetic[J]. Annals of emergency medicine, 1999, 33(5): 495-499.
[4] Sell C. Chemistry of essential oils[M]//Handbook of essential oils. CRC Press, 2020: 161-189.
[5] Du K, McGill M R, Xie Y, et al. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses[J]. Food and Chemical Toxicology, 2015, 86: 253-261.
[6] Cai C, Huang H, Whelan S, et al. Benzyl alcohol attenuates acetaminophen‐induced acute liver injury in a Toll‐like receptor‐4‐dependent pattern in mice[J]. Hepatology, 2014, 60(3): 990-1002.
Benzyl alcohol (Benzenemethanol)是一种芳香醇，广泛应用于医药、化妆品、食品和工业领域[1, 2]。Benzyl alcohol能够被用作短期浅表皮肤手术的局部麻醉剂[3]。Benzyl alcohol是由许多植物自然产生的，通常存在于水果和茶中，也存在于各种精油中[4]。
在体内，Benzyl alcohol（270mg/kg）通过腹腔注射治疗对乙酰氨基酚（APAP）诱导的肝损伤小鼠，显著降低了血浆丙氨酸氨基转移酶（ALT）的活性，减少了肝小叶的坏死面积，减轻了APAP诱导的肝损伤[5]。Benzyl alcohol（270mg/kg）通过腹腔注射治疗治疗对APAP诱导的肝损伤小鼠，抑制了细胞因子和趋化因子以及高迁移率族蛋白1的释放，抑制了炎症小体信号转导[6]。
| Animal experiment [1]: | |
Animal models | C57Bl/6J mice |
Preparation Method | After overnight fasting, mice were treated i.p. with 400mg/kg Acetaminophen (APAP) dissolved in warm saline. Benzyl alcohol (Benzenemethanol) (270mg/kg) dissolved in saline or saline alone (20mL/kg) were co-administered (i.p.) or 2h after APAP. At 0.5h, 2h, 6h or 24h post-APAP mice were euthanized and blood and livers were harvested. Blood was drawn into a heparinized syringe and centrifuged to obtain plasma. The liver was sliced into pieces, and then fixed in phosphate-buffered formalin for histology, or used for mitochondrial isolation, or was snap-frozen in liquid nitrogen and subsequently stored at −80°C. |
Dosage form | 270mg/kg; i.p. |
Applications | Mice treated with 400mg/kg APAP had severe liver injury at 6h and 24h post-APAP, as indicated by increased plasma ALT activities and centrilobular necrosis. Cotreatment with Benzyl alcohol (270mg/kg) significantly attenuated the increase in ALT activities and reduced areas of necrosis at both 6h and 24h, indicating that Benzyl alcohol reduced APAP induced liver injury. |
References: | |
| Cas No. | 100-51-6 | SDF | |
| 别名 | 苄醇; Benzenemethanol | ||
| Canonical SMILES | OCC1=CC=CC=C1 | ||
| 分子式 | C7H8O | 分子量 | 108.14 |
| 溶解度 | Ethanol : ≥ 100 mg/mL, Water : 20 mg/mL, DMSO : ≥ 1.8 mg/mL | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 9.2473 mL | 46.2364 mL | 92.4727 mL |
| 5 mM | 1.8495 mL | 9.2473 mL | 18.4945 mL |
| 10 mM | 924.7 μL | 4.6236 mL | 9.2473 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >99.50% Appearance: A liquid
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