AVE5688

目录号: GC31627纯度: >99.50%

AVE5688是糖原磷酸化酶(glycogenphosphorylase(GP))抑制剂，抑制兔肌肉糖原磷酸化酶rmGPb和rmGPa的活性，IC50值分别为430nM和915nM，Kd值分别为170nM和530nM；AVE5688可用于二型糖尿病的研究。

Cas No.: 613260-13-2

规格	价格	库存	数量
1mg	¥2,340.00	现货	1
5mg	¥3,780.00	现货	1
10mg	¥5,130.00	现货	1

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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
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632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
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33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
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33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively)[1].

[1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91.

实验参考方法 Experimental Reference Method

Kinase experiment:

Glycogen phosphorylase activity is measured in the physiological direction of glycogen breakdown. rmGP is used for the kinetic characterization of the inhibitors (AVE5688). To routinely check the phosphorylation grade of enzyme batches, activity is measured in the direction of glycogen synthesis; the phosphorylation grade is estimated from the ratio of the activity in the presence of 0.5 mM caffeine to the activity in the presence of 2 mM AMP[1].

References:

[1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号

613260-13-2

SMILES

O=C(O)C1=CC=C(NC(NC(C2=CC(F)=C(F)C=C2Cl)=O)=O)C(OC(F)(F)F)=C1

分子式

C₁₆H₈ClF₅N₂O₅

分子量

438.69 g/mol

溶解性

DMSO : 100 mg/mL (227.95 mM; Need ultrasonic)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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