AUTEN-67

AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease.

AUTEN-67 (2-100 µM, 3 h) inhibits MTMR14 by nearly 3%-70%, induces autophagic flux, and promotes the survival in HeLa cells^[1].
AUTEN-67 (10-100 µM, 2 h) induces autophagy in Drosophila via inhibiting EDTP^[1].
AUTEN-67 (1-50 µM) decreases levels of LC3B-II, and protects neurons from oxidative stress (increases cell viability) in murine primary neurons^[1].

AUTEN-67 enhances autophagy in zebrafish (10, 50 µM)and mice (e 50 µmol/g body weight, i.p.)^[1].
AUTEN-67 (19 mg/kg, p.o., 3 times a week, for 3 month) restores nesting behavior and decreases APP level in the Alzheimer disease mice model^[1].

References:
[1]. Papp D, et al. AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 2016;12(2):273-86.