GlpBio

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine

目录号: GC34023纯度: >98%同义词: 卡培立肽,Atrial Natriuretic Peptide (ANP) (1-28), human, porcine
COASDSData Sheet
卡培肽Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) 是一种含 28 个氨基酸的激素,由心脏产生并分泌,以响应心脏损伤和机械拉伸。
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine
Cas No.: 89213-87-6
规格价格库存数量操作
500μg¥1,607.00现货
1
1mg¥2,499.00现货
1
5mg¥8,747.00现货
1
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产品描述 Description

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Carperitide) is a hormone containing 28 amino acids that is produced and secreted by the heart in response to cardiac injury and mechanical stretching[1]. Carperitide is widely used in patients with Heart failure(HF)[2].

Carperitide(1 mM;10min)significantly reduced infarct size in isolated rat hearts[3]. Carperitide inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[4].

Carperitide dose increased, coronary blood flow (CBF) increased, and coronary artery diastole reached saturation at 0.1µg kg -1 min -1, but there was no change in CPP or myocardial oxygen consumption in dog[5].

References:
[1]. Kohno M, Yokokawa K, et,al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7. doi: 10.1161/01.res.70.2.241. PMID: 1310444.
[2]. Mukoyama M, Nakao K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest. 1991 Apr;87(4):1402-12. doi: 10.1172/JCI115146. PMID: 1849149; PMCID: PMC295184.
[3]. Okawa H, Horimoto H, et,al.Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts. Mol Cell Biochem. 2003 Jun;248(1-2):171-7. doi: 10.1023/a:1024148621505. PMID: 12870670.
[4].Kohno M, Yasunari K, et,al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. doi: 10.1172/JCI115228. PMID: 1645748; PMCID: PMC296954.
[5].Asanuma H, Sanada S, et,al.Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO. Hypertens Res. 2014 Aug;37(8):716-23. doi: 10.1038/hr.2014.70. Epub 2014 Apr 3. PMID: 24694647.

卡培肽Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) 是一种含 28 个氨基酸的激素,由心脏产生并分泌,以响应心脏损伤和机械拉伸。Carperitide(重组人ANP)广泛应用于心衰患者[1-2]。

Carperitide显著降低离体大鼠心脏梗死面积[3]。Carperitide抑制ir-Endothelin-1的分泌,增加人脐静脉内皮细胞的环GMP[4].

CBF随着Carperitide剂量的增加而增加,在0.1µg kg-1 min-1剂量时冠状动脉舒张饱和,但CPP(102±2 mm Hg)或心肌耗氧量没有变化[5]。

实验参考方法 Experimental Reference Method

Animal experiment [1]:

Animal models

Female beagle dogs weighing 10–14 kg

Protocol

Protocol: Effects of carperitide on coronary vasodilation in nonischemic hearts.

Five dogs were used. Coronary arterial and venous blood was sampled for blood gas analysis. Myocardial oxygen consumption (ml per 100 g per min) is calculated by coronary blood flow (CBF) (ml per 100 g per min) the oxygen difference between coronary arterial and venous blood (ml dl-1). Measured coronary perfusion pressure (CPP) and CBF after dogs were randomly administered carperitide at a dose of 0.025, 0.05, 0.1 or 0.2 μg kg-1 min-1 into the left anterior descending coronary artery (LAD).

Dosage form

0.025, 0.05, 0.1 or 0.2 μg kg-1 min-1

Applications

CBF increased based on the dose of carperitide, with saturation of coronary vasodilation at a dose of 0.1μg kg−1 min−1despite no changes in CPP (102±2 mm Hg) or myocardial oxygen consumption.

References:

[1]. Asanuma H, Sanada S, et,al. Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO. Hypertens Res. 2014 Aug;37(8):716-23. doi: 10.1038/hr.2014.70. Epub 2014 Apr 3. PMID: 24694647.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
89213-87-6
同义词
卡培立肽,Atrial Natriuretic Peptide (ANP) (1-28), human, porcine
SMILES
Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
分子式
C127H203N45O39S3
分子量
3080.44 g/mol
溶解性
Water: 1 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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