Anti-Mouse PD-L1 Antibody

Anti-Mouse PD-L1 Antibody (10F.9G2) is an IgG2b antibody inhibitor against mouse PD-L1 (CD274/B7-H1), and the host is rat (Rat)^[1]. Anti-Mouse PD-L1 Antibody can be used in animals to block PD-L1^[2]. PD-L1 is one of the ligands of programmed death-1 (PD-1), the other is PD-L2. PD-1 is a member of the CD28 superfamily. Inhibition of the PD-1 pathway accelerates and enhances autoimmunity^[3]. Inhibitors of PD-1 and its ligands, collectively known as immune checkpoint inhibitors, can enhance T cell responses^[4]. PD-L1 is abundantly expressed in many mouse and human cancers and can be further upregulated under IFN-γ stimulation^[5].

References:
[1] Stewart R, Morrow M, Hammond S A, et al. Identification and characterization of MEDI4736, an antagonistic anti–PD-L1 monoclonal antibody[J]. Cancer immunology research, 2015, 3(9): 1052-1062.
[2] Dai S, Jia R, Zhang X, et al. The PD-1/PD-Ls pathway and autoimmune diseases[J]. Cellular immunology, 2014, 290(1): 72-79.
[3] Dong Y, Sun Q, Zhang X. PD-1 and its ligands are important immune checkpoints in cancer[J]. Oncotarget, 2017, 8(2): 2171.
[4] Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer[J]. American journal of cancer research, 2020, 10(3): 727.
[5] He R, Yang X, Liu C, et al. Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model[J]. Cellular & molecular immunology, 2018, 15(9): 815-826.

Anti-Mouse PD-L1 Antibody（10F.9G2）是抗小鼠PD-L1（CD274/B7-H1）的IgG2b抗体抑制剂，宿主是大鼠（Rat）^[1]。Anti-Mouse PD-L1 Antibody可以在动物体内应用，阻断PD-L1^[2]。PD-L1是程序性死亡-1（PD-1）的其中一个配体，另一个是PD-L2，PD-1是CD28超家族成员，PD-1通路的抑制会加速和加强自身免疫^[3]。PD-1以及其配体的抑制剂，通称为免疫检查点抑制剂，能够增强T细胞反应^[4]。许多小鼠和人类癌症中PD-L1的表达丰富，并且在IFN-γ刺激下可以进一步上调^[5]。

Immobilized Mouse PD-L1 Protein (His) (TMPY-01155) at 2 pg/mL (100pL/well) can bind Anti-Mouse PD-L1 Antibody (10F.9G2). The EC50 is 4.08 ng/mL.