Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone.
Anthopleurin-A (2 nM-640 nM) TFA increases the force of contractions of isolated cat heart papillary muscles[2].
Anthopleurin-A (0.2 μg/kg/min i.v.) TFA increases myocardial contractile force in anesthetized dogs[2].
References:
[1]. Honma T, Shiomi K. Peptide toxins in sea anemones: structural and functional aspects. Mar Biotechnol (NY). 2006 Jan-Feb;8(1):1-10.
[2]. Scriabine A, et al. Cardiotonic effects of anthopleurin-A, a polypeptide from a sea anemone. J Cardiovasc Pharmacol. 1979 Sep-Oct;1(5):571-83.
















