Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. Anhydrochlortetracycline showed a rather specific activity against actinomycetes. Preliminary data indicated that the compound showed no obvious toxicity to mice at doses of 160 mg/kg. Anhydrochlortetracycline showed a substantial in vitro activity against N. asteroides and S. salmonicida pathogens of man and fish, respectively [1].
Reference:
[1] Goodman J J, Matrishin M, Backus E J. The effect of anhydrochlortetracycline on the growth of actinomycetes[J]. Journal of bacteriology, 1955, 69(1): 70.