Cefquinome is a broad-spectrum cephalosporin antibiotic.1 It is active against clinical isolates of various Gram-positive and Gram-negative bacteria, including Salmonella, E. coli, and methicillin-resistant S. aureus (MRSA; MICs = 0.06-0.5, 0.015-0.5, and 1-16 ?g/ml, respectively). Intramammary administration of cefquinome (75 mg/animal) is curative in a bovine model of E. coli-induced mastitis.2 Formulations containing cefquinome have been used in the treatment of coliform mastitis in veterinary medicine.
1.Chin, N.-X., Gu, J.-W., Fang, W., et al.In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibioticsDiagn. Microbiol. Infect. Dis.15(4)331-337(1992) 2.Shpigel, N.Y., Levin, D., Winkler, M., et al.Efficacy of cefquinome for treatment of cows with mastitis experimentally induced using Escherichia coliJ. Dairy Sci.80(2)318-323(1996)