Akt-I-1 is an inhibitor of Akt1 (IC50 = 4.6 µM).[1] It is selective for Akt1 over Akt2, Akt3, and serum/glucocorticoid-regulated kinase (SGK; IC50s = >250 µM for all).
References:
[1].Barnett, S.F., Defeo-Jones, D., Fu, S., et al.Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitorsBiochem. J.385(Pt. 2)399-408(2005).
















