Actiphenol is a bacterial metabolite that has been found in Streptomyces and has antiviral activity.1,2 It is active against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/ml, respectively).1 Actiphenol (50 µg/disc) potentiates the antifungal activity of miconazole against C. albicans in a disc assay.2
1.Ji, X.-Y., Zhong, Z.-J., Xue, S.-T., et al.Synthesis and antiviral activities of synthetic glutarimide derivativesChem. Pharm. Bull. (Tokyo)58(11)1436-1441(2010) 2.Fukuda, T., Matsumoto, A., Takahashi, Y., et al.Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132J. Antibiot. (Tokyo)58(4)252-259(2005)