Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene originally isolated from G. biloba and has diverse biological activities.1,2,3,4 It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC50 = 3 μg/ml).1 Ginkgoneolic acid inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM).2 It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC50) value of 4 μg/ml.3 Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.4
1.Irie, J., Murata, M., and Homma, S.Glycerol-3-phosphate dehydrogenase inhibitors, anacardic acids, from Ginkgo bilobaBiosci. Biotechnol. Biochem.60(2)240-243(1996) 2.Guo, J.-F., Ning, Z.-Q., Wu, X., et al.Discovery of a natural PI3Kδ inhibitor through virtual screening and biological assay studyBiochem. Biophys. Res. Commun.508(3)709-714(2019) 3.He, J., Wang, S., Wu, T., et al.Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitroFolia Microbiol. (Praha)58(2)147-153(2013) 4.Yang, X.-m., Chen, S.-x., Xia, L., et al.Molluscicidal activity against Oncomelania hupensis of Ginkgo bilobaFitoterapia79(4)250-254(2008)