6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine[1].
6-Benzoylheteratisine (3 μM) decreases the amplitude of the presynaptic fiber spike at all stimulus intensities tested and shiftes the curve to the right[1].6-benzoylheteratisine is capable of inhibiting stimulus-triggered epileptiform activity recorded in CA1 stratum pyramidale[1].
[1]. A Ameri, et al. Interaction of the structurally related aconitum alkaloids, aconitine and 6-benzyolheteratisine, in the rat hippocampus. Eur J Pharmacol. 1999 Dec 15;386(2-3):187-94.