(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research[1].
References:
[1]. Guiping Zhang, et al. "Discovery of N-substituted (2-phenylcyclopropyl) metlamines as functionally selective serotonin 2C receptor agonists for potential use as antipsychotic medications." Journal of medicinal chemistry 60.14 (2017): 6273-6288.
















