2,3-dinor-11β-Prostaglandin F2α-d9 (2,3-dinor-11β-PGF2α-d9) is intended for use as an internal standard for the quantification of 2,3-dinor-11β-PGF2α by GC- or LC-MS. 2,3-dinor-11β-PG2α was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.1 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.2 In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC-MS) of the immunoreactive 11β-PGF2α when measured using 's 11β-PGF2α EIA Kit . The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.3
1.Liston, T.E., and Roberts, L.J., IIMetabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteerJ. Biol. Chem.260(24)13172-13180(1985) 2.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 3.O'Sullivan, S., Mueller, M.J., DahlÉn, S.E., et al.Analyses of prostaglandin D2 metabolites in urine: Comparison between enzyme immunoassay and negative ion chemical ionization gas chromatography-mass spectrometryProstaglandins Other Lipid Mediat.57(2-3)149-165(1999)