15-deoxy-δ12,14-Prostaglandin J2-biotin

15-deoxy-δ^12,14-Prostaglandin J₂ is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.^1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. 15-deoxy-δ^12,14-PGJ₂-biotin is an affinity probe which allows 15-deoxy-δ^12,14-PGJ₂ to be detected through an interaction with the biotin ligand. 15-deoxy-δ^12,14-PGJ₂-biotin was designed to allow 15-deoxy-δ^12,14-PGJ₂ to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.

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